A Review on Metaanalysis of Biomarkers: Promises and Pitfalls
نویسندگان
چکیده
منابع مشابه
A review on metaanalysis of biomarkers: promises and pitfalls.
BACKGROUND The last 30 years have seen an exponential increase in metaanalyses. By combining multiple studies, metaanalysis can provide an overview of the totality of evidence on a particular question and the statistical power needed to reduce random error and produce precise estimates of even modest effect sizes. This capability is of particular value when many small studies address similar qu...
متن کاملNon-invasive Biomarkers in Asthma: Promises and Pitfalls
The asthma concept has evolved throughout the years: one major step in asthma management is the recognition of the chronic (airway) inflammation; another major step is further understanding of asthma heterogeneity and subsequent development of targeted therapies. While the concept of chronic inflammation, airway structural changes and their variability over time are widely accepted, their measu...
متن کاملThe Promises And Pitfalls Of
Evidence-based medicine (EBM) aims to address the persistent problem of clinical practice variation with the help of various tools, including standardized practice guidelines. While advocates welcome the stronger scientific foundation of such guidelines, critics fear that they will lead to “cookbook medicine.” Studies show, however, that few guidelines lead to consistent changes in provider beh...
متن کاملPromises and Pitfalls of Polarimetry
Imagine an observational technique, differential in nature, that takes full advantage of the information content a photon has to offer. Photometric conditions would be unecessary, allowing groundbased telescopes to outsrip their space-based counterparts for uses where imaging is not required. Indeed, such a technique has been around for decades in the form of polarimetry. Why, then, are the num...
متن کاملPersonalized Medicine: Promises and Pitfalls
The US Food and Drug Administration (FDA) describes personalized medicine as “the right patient with the right drug at the right dose at the right time,” and it certainly is a timely and emerging medical practice. Personalized Medicine: Promises and Pitfalls, by Gloria Gronowicz, begins with a unique perspective: the author’s own personal anecdote about the very day she was diagnosed with stage...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2012
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2012.184226